tES / Neuromodulation
Research exploring how low-intensity electrical currents modulate neural activity, membrane potentials, and neuroplasticity.
Evidence
Building evidence through neuromodulation mechanisms, engineering validation, and clinical research
This page aggregates the team's research and development outcomes. We do not claim our products treat specific diseases; product indications and clinical use are subject to regulatory clearance.
HD-tES / Multi-channel
High-definition electrode configurations and multi-channel control support targeted stimulation and personalized research designs.
fNIRS Monitoring
Using hemoglobin changes and brain activation as functional metrics to support pre/post intervention tracking and neurofeedback.
DTx Home Tracking
Digital platforms supporting task adherence and outcome tracking, exploring the transition from in-hospital research to home care.
Innovation recognition
National Innovation Award
Precision neuromodulation and digital therapeutics based on real-time brain activity
Prof. Jia-Jin Chen's team integrated HD-tES, fNIRS, and DTx to develop a research platform for precision neuromodulation and outcome tracking based on brain activity.
This award recognizes technological innovation and R&D outcomes. It does not imply that specific products have obtained medical device clearance or guarantee clinical efficacy.
Team publications
Published Evidence
The following studies co-authored by Prof. Jia-Jin Chen and Prof. Yi-Jing Huang serve as supporting evidence for neural engineering, feasibility, and pilot clinical research.
2025Depression and Anxiety
Hypoactivity of the Prefrontal Cortex During Go/No-Go Task in Patients With Generalized Anxiety Disorder
Chien-An Chen, Po-Tsen Lin, Meng-Yu Hsu, Cheng-Yang Lee, I-Ming Chen, Yi-Ting Lin, Yu-Jui Huang, Pao-Huan Chen, Jia-Jin Chen, Gong-Hong Lin, Yi-Jing Huang
This fNIRS study examined prefrontal hemodynamic activity during a Go/No-Go inhibitory-control task in patients with generalized anxiety disorder. The findings showed reduced prefrontal activity during baseline and task states, supporting prefrontal function as an important research direction for anxiety regulation and cognitive control. This is research evidence and does not imply regulatory clearance for diagnosis or treatment of anxiety disorders.
DOI 10.1155/da/90401152022Pilot randomized controlled trial
High-Definition Transcranial Direct Current with Electrical Theta Burst on Post-Stroke Motor Rehabilitation: A Pilot Randomized Controlled Trial
Neurorehabilitation and Neural Repair, 36(9), 645–654
This patient-blinded pilot randomized controlled trial with 24 chronic stroke participants evaluated the safety and therapeutic potential of HD-tDCS-eTBS combined with conventional upper limb rehabilitation. No serious adverse events occurred, and findings support further large-scale studies without constituting a guarantee of efficacy.
DOI 10.1177/154596832211217512021Device design & pilot testing
Designing and pilot testing a novel high-definition transcranial burst electrostimulation device for neurorehabilitation
Journal of Neural Engineering, 18(5):056030
This study designed and pilot-tested a novel high-definition transcranial burst electrostimulation device for neurorehabilitation, providing preliminary safety and feasibility evidence for the NeuraStim/HD-tES platform in engineering design and translational research.
DOI 10.1088/1741-2552/ac23beResearch Evidence and Regulatory Statement
The outcomes above represent pilot studies, engineering validation, and supporting evidence. Individual study results do not equate to product clearance for treating stroke or other diseases, nor do they guarantee personal improvement. All clinical uses must be subject to regulatory clearance, medical professional judgment, and official product labeling.